Imodium Multi-Symptom Relief Caplets are the only over-the-counter brand of antidiarrheal medicine that combines two powerful medicines to relieve symptoms of diarrhea as well as gas, cramps, pressure, and bloating. Each caplet contains 2 milligrams of Loperamide Hydrochloride to help relieve diarrhea and 125 milligrams of Simethicone to help other associated symptoms.